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Xanax is prescription tranquilizer which depresses the nervous system in a way similar to alcohol. Xanax has found its way from pharmacies to drug dealers, and is being abused by young, healthy people who want to get high. These club-hopping, twenty-something, casual ``Xannie poppers'' are using the drug in combination with other stimulants, from alcohol to cocaine. Used to treat many disorders from anxiety to stress, Xanax addiction results in the overuse of the drug to suppress unwanted feelings. Whether the drug is taken every night to fall asleep or continually throughout the day to remain calm, Xanax addiction progresses quickly and has become a serious health problem for many people. Xanax when abused is taken orally, chewed, crushed (then snorted like cocaine), or crushed (then dissolved in water and injected like heroin). Xanax has depressant effects on brain areas that regulate wakefulness and alertness, very similar in effect to alcohol and sedative barbiturates. Xanax enhances the action of receptors that inhibit central nervous system stimulation, and conversely, inhibit the action of receptors that stimulate the nervous system. In other words, if the nervous system were a car, these drugs help press down the brakes but make it harder to press down on the gas. Essentially, withdrawal symptoms from Xanax feel like the opposite of the therapeutic effects. Xanax withdrawal can produce especially severe withdrawal symptoms. Withdrawal symptoms that are similar to those in alcohol withdrawal, include jittery, shaky feelings and any of the following: While xanax (Xanax) seems to be the most effective agent in stopping clusters of panic attacks (see article above), people should be aware of the potential problems and side effects of this medication. This applies to other benzodiazepines (BDZ's) as well. Above all, one must make sure that the diagnosis as correct before starting xanax. It is most useful in the "classic" generational PNE with childhood onset; gastroesophageal reflux or irritable bowel syndrome, with panic attacks not phobic anxiety. Panic attacks and phobic anxiety are often confused. Panic attacks occur "from nowhere" often waking the person up from sleep or while the person is relaxing after work. As the untreated condition progressive anticipatory or phobic reactive attacks frequently develop and may overshadow the original true panic attacks. The DSM-IV diagnostic criterion is too broad and would include people with toxic based panic attacks and phobic syndromes as well as posttraumatic stress disorder (PTSD). The prescribing doctor needs to do a careful diagnostic examination to insure proper diagnosis. It takes at least an hour. Beware of physicians that pronounce your diagnosis as panic disorder after just a few minutes of discussion. If you do not feel that you have the more rigorous criterion for panic disorder as described above and in the rest of this site, then you might want to deal with your anxiety problem through cognitive behavioral therapy (CBT). A Xanax overdose happens when you consume more Xanax than your body can safely handle. Xanax abusers are constantly flirting with drug overdose, and the difference between the high they're seeking and serious injury or death is often quite small. An overdose of Xanax, alone or after combining it with alcohol, can be fatal. The major concern about xanax has been the so-called "idiosyncratic reaction". People taking xanax can become disinhibited, violent or have marked personality changes. As I understand it, this is why Halcion and xanax are prohibited in the UK. In my experience this does not occur in people with panic disorder, but does occur in people with anxiety due to personality disorder or other psychiatric conditions. I have not seen documentation of this reaction in PNE. When xanax first came out it was considered "another Valium" and was often prescribed as a general tranquilizer in many different diagnostic categories. (NewsRx.com) -- IMPAX Laboratories, Inc. (OTC:IPXL) announced that the U.S. Food and Drug Administration (FDA) has granted final approval of the Company's Abbreviated New Drug Application (ANDA) for generic versions of Xanax(R) XR, (xanax) 0.5 mg, 1 mg, 2 mg and 3 mg Extended-release Tablets. Pharmacia and Upjohn markets Xanax XR for the management of anxiety disorder or the short-term relief of symptoms of anxiety. IMPAX' Global Pharmaceuticals division plans to launch the product soon. It's also quite addictive. "Xanax is extremely potent," says Dr. Steven Juergens of Virginia Mason University, who was the first to write about Xanax addiction, in 1988. "It acts quickly on the brain and has a short half-life." Users of such drugs tend to come back for more and more. Xanax is also used by partygoers as a "parachute" drug to bring them down from the effects of stimulants such as ecstasy. It's this combination of drugs, suggests Dr. Herbert Kleber, a professor of psychiatry at Columbia University, that may account for the current interest in Xanax. Like most doctors, I've watched with concern the growing use of so-called club drugs--psychotropic substances that catch on from time to time among teenagers and young adults and become the rage at dance clubs and all-night raves. I know about ecstasy, Rohypnol and ketamine. But I was taken by surprise last week when Noelle Bush, daughter of Florida Governor Jeb Bush (and the President's niece), was arrested in Tallahassee trying to buy Xanax, having allegedly borrowed the name of a retired doctor and called in a bogus prescription. Xanax, after all, is a widely prescribed antianxiety medication--a cousin of Valium--and hardly fits the profile of a Gen X party drug. Except for the historical information contained herein, the statements made in this press release constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements can be identified by their use of words such as "expects," "plans," "projects," "will," "may," "anticipates," "believes," "should," "intends," "estimates" and other words of similar meaning. Because such statements inherently involve risks and uncertainties that cannot be predicted or quantified, actual results may differ materially from those expressed or implied by such forward-looking statements depending upon a number of factors affecting the Company's business. These factors include, among others: the difficulty in predicting the timing and outcome of legal proceedings, including patent-related matters such as patent challenge settlements and patent infringement cases; the outcome of litigation arising from challenging the validity or non- infringement of patents covering our products; the difficulty of predicting the timing of FDA approvals; court and FDA decisions on exclusivity periods; the ability of competitors to extend exclusivity periods for their products; our ability to complete product development activities in the timeframes and for the costs we expect; market and customer acceptance and demand for our pharmaceutical products; our dependence on revenues from significant customers; reimbursement policies of third party payors; our dependence on revenues from significant products; the use of estimates in the preparation of our financial statements; the impact of competitive products and pricing on products, including the launch of authorized generics; the ability to launch new products in the timeframes we expect; the availability of raw materials; the availability of any product we purchase and sell as a distributor; the regulatory environment; our exposure to product liability and other lawsuits and contingencies; the increasing cost of insurance and the availability of product liability insurance coverage; our timely and successful completion of strategic initiatives, including integrating companies and products we acquire and implementing our new enterprise resource planning system; fluctuations in operating results, including the effects on such results from spending for research and development, sales and marketing activities and patent challenge activities; the inherent uncertainty associated with financial projections; changes in generally accepted accounting principles; and other risks detailed from time-to-time in our filings with the Securities and Exchange Commission, including in our Annual Report on Form 10-K for the fiscal year ended June 30, 2005. Xanax is usually used to relieve panic and anxiety, which may be why Noelle wanted it. But though it ranks low on the scale of drugs most likely to be abused (heroin is termed a Schedule I drug; Xanax is a Schedule IV), the Drug Enforcement Administration has been keeping a close eye on it for years. Like other benzodiazepines, it acts on the neurotransmitter gamma-aminobutyric acid, decreasing brain activity and producing a drowsy or calming effect. "It's like being drunk, without the toxicity of alcohol," reports a helpful chat-room participant. Benzodiazepine abuse is on the rise, according to the Health and Human Service's Drug Abuse Warning Network. But so is prescription-drug abuse generally. From 1990 to '98, National Institute on Drug Abuse statistics show, the number of Americans who started misusing sedatives nearly doubled, while abuse of pain relievers rose 180%. Because the drug is extremely addictive, Xanax is only approved by the FDA for up to 8 weeks of use and it is only approved for only 4 weeks of use in Great Britain. It is proven that, if the greater the dose is taken, the faster one becomes dependant. If one uses these drugs long term, the body will develop tolerance for the drugs, and larger doses will be needed to achieve the same initial effects. Patients typically notice relief of insomnia initially, followed by a gradual loss of efficacy. In addition, continued use can lead to physical dependence and - when use is reduced or stopped the body goes through. Xanax is rarely abused as a sole drug. Almost 80 percent of benzodiazepine abuse is part of poly-drug abuse, most commonly with opioids. There is also very expressed and present co-abuse with alcohol. Studies indicate that 3 to 41 percent of alcoholic persons report that they abused benzodiazepines at some time, often to modulate intoxication or withdrawal effects. As potential drugs of abuse, short-acting benzodiazepines seem to be preferred among addicts because of the rapidity of their onset of action. We don't really know what Noelle Bush planned to do with those 40 Xanax pills in the prescription or even whether she was getting them for herself. Her parents issued a terse statement acknowledging that the family is "deeply saddened" and reminding Americans that "substance abuse is an issue confronting many families across our nation." Noelle's mother Columba should know. As a board member of the Center on Addiction and Substance Abuse at Columbia University, she has helped raise awareness about the problem. Sadly, nothing she's done over the years has attracted nearly as much attention as her daughter's arrest. U.S. sales of the combined branded and generic 0.5 mg, 1 mg, 2 mg and 3 mg dosage forms were approximately $51 million in the 12 months ended March 2007, according to Wolters Kluwer Health. For the addict, admitting they have an addiction problem can be the most difficult part of a rehab program. However painful this may be, it must be acknowledged as the first gradient to overcoming the problem. The next hurdle is being willing to seek and accept help from an addiction professional. Most people think that detox-therapy is enough! Well, that of course isn't true! Detoxification is only the first step on the road of addiction treatment. Physical detoxification alone is not sufficient to change the patterns of a drug addict. During the rehab period, the addict needs new tools in order to deal with situations and problems which will eventually arise in perspective. Most of the addicts, even when they do admit that they have problem, rarely choose to talk with some professional about it. When an addict makes an attempt at detoxification and to discontinue drug use without the aid of professional help, statistically the results do not last long. In specialized Detox Centers, addicts are treated with respect. The dose of the drug is gradually reduced and the help is given to battle all the possible withdrawal symptoms. Battling not only suppress their drug of choice, but it is also re-stimulating their past and changes in the way their brain functions. Therefore, it is no wonder that quitting drugs without professional help is an uphill battle. "This is our third FDA approval this year and we are looking forward to adding our generic Xanax XR to the growing portfolio of our marketed products," said Larry Hsu, Ph.D., IMPAX's president and chief executive officer. xanax, trade name Xanax, is a short-acting drug in the benzodiazepine class used to treat anxiety disorders and as an adjunctive treatment for depression. xanax is also effective in the treatment of activity depression or panic attacks. It can also be useful in treating irritable bowel syndrome and anxiety due to a neurosis. Problem with this medication is that, both- tolerance and dependence can occur with the use of Xanax and person may experience withdrawal symptoms if stop using the drug abruptly. The drug dosage should be gradually reduced and only doctor should advise on how to discontinue or change dose. Biotechnology, Drug Development, Drugs, FDA, Pharmaceuticals, Psychiatry, Regulatory Actions, Therapy, Treatment, U.S. Food and Drug Administration, Xanax Xr, IMPAX Laboratories Inc. Dependency is an issue. Some people will find that they cannot discontinue xanax. It is highly variable and dependency will be most pronounced in people who take higher dosages, are older and have taken it for a long period of time. It is estimated that as many as 1/3 of people who take xanax for a year will experience inability to discontinue xanax or prolonged, uncomfortable discontinuation symptoms. Unless a person is willing to risk the possibility of long-term use of xanax, they should not start it at all. While dependency is a concern, when used for generational PNE the same dosage has been shown to be effective over long periods of time (a good long term study I have read was by Lessor et al at UCLA in which 20 year follow-up was done and the patients did not find that xanax lost effectiveness and that dosage tended to decrease slightly over time. The average patient was taking between 3 mg and 5 mg daily). Tolerance to the therapeutic effect of xanax is quite rare, and if it occurs then the drug should be stopped. People often ask about whether xanax can cause "permanent brain damage." Some uncontrolled anecdotal reports have shown enlargement of the ventricles in people who have used BDZ's for long periods of time, but to date, there is not clinical or research evidence that long term use of the BDZ's causes brain damage. Long-term use of BDZ's is not associated with cancer and may be negatively associated with pancreatic cancer. Since PNE is associated with increased morbidity and mortality from cardiovascular causes it is possible (but never studied) that long term BDZ use may reduce this risk. Certainly many people with hypertension and PNE find that xanax lowers blood pressure. The withdrawal symptoms from Xanax and other benzodiazepines are quite similar, with the exception that Xanax has a much higher incidence of panic attack and a bereavement type of emotional liability that is singularly more severe. When we talk about withdrawal effects from therapeutic dosages of benzodiazepines, then we should know that they are mainly anxiety symptoms. Some people also experienced autonomic instability, insomnia and sensory hypersensitivity. The most serious acute withdrawal symptoms are seizures and delirium tremens, which most commonly occur with abrupt discontinuation. Symptoms of Xanax abuse withdrawal are much more dramatic because they include effects which occur after much longer period of usage! The most common are: anxiety, blurred vision, decreased concentration, decreased mental clarity, depression, diarrhea, headache, heightened awareness of noise or bright lights, hot flushes, impaired sense of smell, insomnia, loss of appetite, loss of reality, muscle cramps, nervousness, rapid breathing, seizures, tingling sensation, tremor, twitching, weight loss… Memory impairment is a common side effect. This seems to be mild but fairly common. Many people on xanax notice memory loss, but others will have memory loss but will not notice it. Studies have shown that verbal recall seems to be most affected by xanax. Short-term memory is much more prone to problems than long-term memory. Memory problems are very common with panic anxiety, but I have not seen a controlled study, which compares memory problems with xanax to memory problems in PNE. Some people actually find memory improved on xanax since the "blanking out" of memory with anxiety is improved. Still, people who take xanax often note problems with memory. Because the management of panic disorder often requires the use of average daily doses of Xanax above 4 mg, the risk of dependence among panic disorder patients may be higher than that among those treated for less severe anxiety. Experience in randomized placebo-controlled discontinuation studies of patients with panic disorder showed a high rate of rebound and withdrawal symptoms in patients treated with Xanax compared to placebo-treated patients. Early morning anxiety and emergence of anxiety symptoms between doses of Xanax have been reported in patients with panic disorder taking prescribed maintenance doses of Xanax. These symptoms may reflect the development of tolerance or a time interval between doses which is longer than the duration of clinical action of the administered dose. In either case, it is presumed that the prescribed dose is not sufficient to maintain plasma levels above those needed to prevent relapse, rebound or withdrawal symptoms over the entire course of the interdosing interval. In these situations, it is recommended that the same total daily dose be given divided as more frequent administrations (see DOSAGE AND ADMINISTRATION). Relapse or return of illness was defined as a return of symptoms characteristic of panic disorder (primarily panic attacks) to levels approximately equal to those seen at baseline before active treatment was initiated. Rebound refers to a return of symptoms of panic disorder to a level substantially greater in frequency, or more severe in intensity than seen at baseline. Withdrawal symptoms were identified as those which were generally not characteristic of panic disorder and which occurred for the first time more frequently during discontinuation than at baseline. order Xanax saturday delivery
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